A trio of big names headline these NFL Week 6 prop bets.
The pregame narrative: Davante Adams and Ladd McConkey have been the No. 2 options on their respective teams so far. But that’s led to a pair of manageable lines I want to exploit. Elsewhere, I expect Christian McCaffrey to be active as a pass catcher against the Tampa Bay Buccaneers.
Check out my top Week 6 NFL prop bets.
NFL prop bets: Week 6
Best bet: Adams over 63.5 receiving yards (-118)
The Baltimore Ravens’ defence is in a tailspin, and a bad result on Sunday could very well cost coordinator Zach Orr his job.
That’s no exaggeration. Just look at how the unit has performed so far:
- 32nd in points per game (35.4)
- 31st in yards per game (408.8)
- 30th in EPA per play (+0.186)
- 29th in EPA per dropback (+0.244)
Enter the Los Angeles Rams, who have a rest advantage after playing on Thursday Night Football.
You could make a good argument for any player to smash their receiving or rushing total, but I think Adams stands out for a few reasons.
According to Rotowire, the veteran ranks in the 90th percentile or higher in air yards per game (109.6), team target rate (25.4%) and targets per route (27.1%) among all WRs.
Puka Nacua is the top dog, but there’s plenty of love to go around.
Key stat: The Ravens are allowing the ninth-most receiving yards per game to WRs (159), per Football Reference.
Best NFL picks
McConkey over 55.5 receiving yards (-118): McConkey is having a very slow start to the season after a great rookie campaign.
- 2024: 5.1 catches and 71.8 yards per game
- 2025: 4.2 catches and 42.6 yards per game
The emergence of Quentin Johnston as a reliable target and the acquisition of Keenan Allen have really cut into his production.
But McConkey still leads the squad in route participation, and Johnston (hamstring) was limited at practice on Wednesday.
Also, Omarion Hampton is on injured reserve, which should mean a more pass-heavy attack for Jim Harbaugh’s group.
Add in the fact that McConkey is going up against a Miami Dolphins defence ranking 30th in EPA per dropback, and I think we have a recipe for a breakout game.
Christian McCaffrey over 6.5 receptions (-106): This type of line is typically reserved for star wide receivers, but you could argue CMC is position-agnostic.
He has the second-most receptions (39) and sixth-most receiving yards (387) among all players in the NFL.
McCaffrey is 3-2 against this line, landing on exactly six receptions in both outlying games.
I don’t think the San Francisco 49ers will be able to run the ball well against Tampa Bay’s defence (No. 1 in EPA per rush).
That just means Kyle Shanahan will have to find other ways to get the ball into the hands of his best playmaker.
NFL prop bets made at 2:30 p.m. ET on 10/09/2025.
Avery joined NorthStar Gaming as an intern in 2022 before stepping into a full-time role soon after. He loves betting on and analyzing golf — mainly because it’s easier than actually playing — but is a fan of all sports, from the NFL to the UFC.