March Madness Sweet 16 odds, schedule and matchups: All four No. 1 seeds are heavy favourites

March Madness Sweet 16 odds

March Madness’ first weekend was fairly chalky but that means there are some great matchups on deck.

The latest: All four No. 1 seeds are alive and each is a sizeable favourite in the Sweet 16. John Calipari’s No. 10 Arkansas Razorbacks are the only double-digit seed remaining and they’re slim underdogs to the Texas Tech Red Raiders.

Check out the latest March Madness Sweet 16 odds and the full schedule for this week’s games.

March Madness Sweet 16 odds

Thursday’s schedule

BYU Cougars (6) vs. Alabama Crimson Tide (2)
Thursday, March 27: 7:09 p.m. ET

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Alabama survived a scare in the first round but responded with a blowout win over the No. 5 Saint Mary’s Gaels.

The Crimson Tide allow 81.0 points per game (346th in D-I) and overs are 19-15-1 in their games. Overs are 21-14 for BYU. This 175 total is by far the highest on the slate.

Maryland Terrapins (4) vs. Florida Gators (1)
Thursday, March 27: 7:39 p.m. ET

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Florida eked out a win over the two-time reigning champion UConn Huskies thanks to clutch shotmaking by All-American Walter Clayton Jr.

The Terrapins won on the first and only buzzer-beater of the tournament and have covered a +7 spread in every game this season.

Arizona Wildcats (4) vs. Duke Blue Devils (1)
Thursday, March 27: 9:39 p.m. ET

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The Blue Devils look really, really good. With Cooper Flagg firing on all cylinders, Duke authored a pair of no-doubt wins in the opening rounds.

Arizona has a 10-11 record against Quad 1 opponents, losing six of its last 10 such games.

Arkansas Razorbacks (10) vs. Texas Tech Red Raiders (3)
Thursday, March 27: 10:09 p.m. ET

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Coach Calipari is back in the Sweet 16 for the first time since 2019. And all it took was moving to Arkansas from Kentucky and dethroning the No. 2 St. John’s Red Storm in the second round.

The Razorbacks have won four of their last five Quad 1 games and are 9-7 ATS as an underdog.

March Madness Sweet 16 odds: Friday’s schedule

Ole Miss Rebels (6) vs. Michigan State Spartans (2)
Friday, March 28: 7:09 p.m. ET

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Tom Izzo and the Spartans haven’t advanced past the Sweet 16 since 2019, and they’ll be in tough against a Rebels team coming off a statement win.

Ole Miss blew out the No. 3 Iowa State Cyclones and is the shortest underdog on this slate.

Kentucky Wildcats (3) vs. Tennessee Volunteers (2)
Friday, March 28: 7:39 p.m. ET

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An all-SEC matchup between Kentucky and Tennessee headlines the slate. The Wildcats are 5-1 in their last six games against the Volunteers, winning twice this year as an underdog.

Tennessee is favoured yet again and will hope for a better result.

Michigan Wolverines (5) vs. Auburn Tigers (1)
Friday, March 28: 9:39 p.m. ET

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Auburn put its shaky end to the regular season in the rearview with two double-digit wins in the opening rounds.

Michigan, meanwhile, has been riding high since its Big Ten title and just sent the No. 4 Texas A&M Aggies packing. The Wolverines are 7-2 ATS as an underdog this season.

Purdue Boilermakers (4) vs. Houston Cougars (1)
Friday, March 28: 10:09 p.m. ET

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Purdue has a Zach Edey-sized hole in its frontcourt and that could be its undoing against a roughrider Houston squad.

The Boilermakers had an easy route to the Sweet 16 facing the No. 12 McNeese Cowboys in the second round, but are 1-6 in their last seven Quad 1 games.

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Avery joined NorthStar Gaming as an intern in 2022 before stepping into a full-time role soon after. He loves betting on and analyzing golf — mainly because it’s easier than actually playing — but is a fan of all sports, from the NFL to the UFC.