{"id":387748,"date":"2025-12-22T11:07:18","date_gmt":"2025-12-22T16:07:18","guid":{"rendered":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/?p=387748"},"modified":"2025-12-22T11:07:18","modified_gmt":"2025-12-22T16:07:18","slug":"49ers-vs-colts-mnf-week-16-td-picks-2025","status":"publish","type":"post","link":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/49ers-vs-colts-mnf-week-16-td-picks-2025\/","title":{"rendered":"49ers vs. Colts Week 16 TD picks: Bet on San Francisco&#8217;s Kittle, Jennings to score"},"content":{"rendered":"\n<p>The San Francisco 49ers and Indianapolis Colts square off in a pivotal Monday Night Football matchup.<\/p>\n\n\n\n<p><strong>The pregame narrative:<\/strong> San Francisco and Indianapolis are both fighting for playoff positioning. The former has a legitimate shot at winning its division (and potentially the No. 1 seed in the NFC) while the latter needs to stay alive. In a game full of superstars, which players will step up?<\/p>\n\n\n\n<p>Check out my 49ers vs. Colts TD picks for Monday Night Football on Dec. 22.<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">Join NorthStar Bets to start betting on the NFL<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs. Colts TD picks<\/h2>\n\n\n\n<p><strong>Best bet: Jennings to score a TD (+150)<\/strong><\/p>\n\n\n\n<p>Some wide receivers have a knack for scoring touchdowns.<\/p>\n\n\n\n<p>Jennings has emerged as one of those receivers.<\/p>\n\n\n\n<p>The 49ers star had six scores last season as he upgraded from a role player to a prominent part of the offence.<\/p>\n\n\n\n<p>Injuries to Ricky Pearsall and Brandon Aiyuk have created significant opportunities for Jennings, and he is taking advantage.<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">Bet on Jennings to score at +150 on Monday Night Football<\/a><\/strong><\/p>\n\n\n\n<p>Jennings scored two touchdowns last week in San Francisco&#8217;s 37-24 win over the Tennessee Titans.<\/p>\n\n\n\n<p>The connection between Brock Purdy and Jennings is too strong to ignore. Since Purdy&#8217;s return in Week 11, Jennings leads all 49ers in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Red-zone targets (seven)<\/li>\n\n\n\n<li>Targets inside the 10 (four)<\/li>\n\n\n\n<li>Targets inside the five (three)<\/li>\n<\/ul>\n\n\n\n<p>Indianapolis also profiles as a strong matchup for opposing wide receivers. The Colts are without starting corners Charvarius Ward and Sauce Gardner, and are allowing the most receptions to wideouts in the NFL (190).<\/p>\n\n\n\n<p>Bet on Jennings to find pay dirt in primetime.<\/p>\n\n\n\n<p><strong>Key stat:<\/strong> Jennings leads the 49ers in targets inside the five-yard line (four).<\/p>\n\n\n\n<p><a href=\"cacheembed:122343\">Embed: #122343<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Monday Night Football anytime TD prediction<\/h3>\n\n\n\n<p><strong>Kittle to score a TD (+123):<\/strong> Like Jennings, Kittle is also one of Purdy&#8217;s top options in close.<\/p>\n\n\n\n<p>Since Purdy&#8217;s return, Kittle is second on the Niners in targets inside the 10 (three) and targets inside the five (two).<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">See full 49ers vs. Colts MNF betting markets<\/a><\/strong><\/p>\n\n\n\n<p>Kittle notched a touchdown in Week 15, and he&#8217;s a good bet to return to the end zone in Week 16.<\/p>\n\n\n\n<p>The Colts are struggling to limit opposing tight ends. Indianapolis is tied for ceding the sixth-most receptions (86) and fifth-most receiving yards (928) to the position.<\/p>\n\n\n\n<p>San Francisco is short on receiving options. Kittle should be at the forefront of the team&#8217;s offensive attack and a top target near the end zone.<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">Sign up to NorthStar Bets today<\/a>!<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The San Francisco 49ers and Indianapolis Colts square off in a pivotal Monday Night Football matchup. The pregame narrative: San Francisco and Indianapolis are both fighting for playoff positioning. The former has a legitimate shot at winning its division (and potentially the No. 1 seed in the NFC) while the latter needs to stay alive. [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":387834,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"sidebar_plugin_meta_block_field":"","footnotes":""},"categories":[61],"tags":[181],"class_list":["post-387748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl","tag-nfl"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>49ers vs. Colts TD picks: 2025 MNF Week 16 | The Boost<\/title>\n<meta name=\"description\" content=\"Check out our 2025 Week 16 49ers vs. Colts TD picks. 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NFL betting odds, prop predictions for Monday Night Football in Indianapolis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/49ers-vs-colts-mnf-week-16-td-picks-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"The Boost\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-22T16:07:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nsb-news.s3.ca-central-1.amazonaws.com\/imgs\/2025\/12\/Kittle_Jennings_122225.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Steven Psihogios\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@StevenPsihogios\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Steven Psihogios\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/49ers-vs-colts-mnf-week-16-td-picks-2025\/\",\"url\":\"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/49ers-vs-colts-mnf-week-16-td-picks-2025\/\",\"name\":\"49ers vs. Colts TD picks: 2025 MNF Week 16 | The Boost\",\"isPartOf\":{\"@id\":\"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/#website\"},\"datePublished\":\"2025-12-22T16:07:18+00:00\",\"dateModified\":\"2025-12-22T16:07:18+00:00\",\"author\":{\"@id\":\"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/#\/schema\/person\/0ec170ba58f3e798902f07cb43c406ea\"},\"description\":\"Check out our 2025 Week 16 49ers vs. Colts TD picks. 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