{"id":387612,"date":"2025-12-20T15:23:18","date_gmt":"2025-12-20T20:23:18","guid":{"rendered":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/?p=387612"},"modified":"2025-12-20T15:23:19","modified_gmt":"2025-12-20T20:23:19","slug":"49ers-vs-colts-week-16-monday-night-football-picks-2025","status":"publish","type":"post","link":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/49ers-vs-colts-week-16-monday-night-football-picks-2025\/","title":{"rendered":"49ers vs. Colts Week 16 Monday Night Football picks: Back the over, George Kittle to have another star performance"},"content":{"rendered":"\n<p>The San Francisco 49ers look to win their fifth straight game when they visit the Indianapolis Colts on Monday night.<\/p>\n\n\n\n<p><strong>The pregame narrative:<\/strong> The 49ers are getting healthy and at the right time. They are averaging 31.0 points per game during their winning streak and have another opportunity to put up a ton of points against a struggling Colts&#8217; defence.<\/p>\n\n\n\n<p>Check out my 49ers vs. Colts picks for Dec. 22, featuring a prop bet on George Kittle.<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">Join NorthStar Bets to start betting on the NFL<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs. Colts picks<\/h2>\n\n\n\n<p><strong>Best bet: Kittle over 66.5 receiving yards (-109)<\/strong><\/p>\n\n\n\n<p>When healthy, Kittle is the cream of the crop at the tight end position.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>He has cleared this yardage total in five straight games.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>During that time, he averaged 6.6 catches on 7.8 targets for 76.8 receiving yards.<\/li>\n<\/ul>\n\n\n\n<p>Those are top wide receiver numbers rather than numbers you&#8217;d typically see out of a tight end.<\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <\/strong><a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\"><strong>Don&#8217;t miss out \u2014 Bet on Monday Night Football<\/strong><\/a><strong>!<\/strong><\/p>\n\n\n\n<p>And this line is on the low end for a pass catcher of his calibre. <\/p>\n\n\n\n<p>Then, take into account the matchup, and this starts to look like a smash play.<\/p>\n\n\n\n<p>The Colts give up the second-most passing yards per game (247.6). On a team without an elite receiver, Kittle should be targeted early and often by Brock Purdy.<\/p>\n\n\n\n<p><strong>Key stat:<\/strong> Indianapolis also allows the fifth most yards per game to opposing tight ends (66.2).<\/p>\n\n\n\n<p class=\"product_only\"><a href=\"cacheembed:122302\">Embed: #122302<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">MNF over\/under pick<\/h3>\n\n\n\n<p><strong>Over 46 points (-109):<\/strong> I believe both teams can contribute enough to cover this modest total on Monday.<\/p>\n\n\n\n<p>As previously mentioned, the Colts have a terrible pass defence, but it doesn&#8217;t stop there. They also allow opponents to convert 41.4% of third downs.<\/p>\n\n\n\n<p>That allows teams to consistently move the chains and run up the score.<\/p>\n\n\n\n<p>On the other side, the 49ers don&#8217;t have the great defence of seasons past. They have a below-average unit that is highlighted by allowing 227.6 passing yards per game (11th worst in the NFL).<\/p>\n\n\n\n<p><strong>-&gt; <\/strong><a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\"><strong>Go to full MNF prop markets now<\/strong><\/a><strong>!<\/strong><\/p>\n\n\n\n<p>Philip Rivers looked his age in Week 15, but the Seattle Seahawks have a far superior defence. In fact, they allow the second fewest points per game.<\/p>\n\n\n\n<p>So it makes sense the Colts&#8217; offence was held to 16 points, but even one more touchdown should be enough to push this game over its total.<\/p>\n\n\n\n<p>I foresee the 49ers doing most of the heavy lifting, though. The offence is as healthy as it&#8217;s been all season, and Purdy is coming off his best game of the season (three touchdowns, zero interceptions).<\/p>\n\n\n\n<p>San Francisco scored 37 points in that game against the Tennessee Titans, and it finished with a total of 61 points.<\/p>\n\n\n\n<p>The Colts&#8217; offence is just as good as the Titans&#8217;, even with Rivers, so a similar result should be expected this week.<\/p>\n\n\n\n<p><em>49ers vs. Colts picks made at 2:35 p.m. ET Dec. 20, 2025.<\/em><\/p>\n\n\n\n<p class=\"acq_only\"><strong>-&gt; <a href=\"https:\/\/online.northstarbets.ca\/page?key=ej0xMzUyNDU3MiZsPTEzNjY1NzMyJnA9MzExMjU%3D\">Sign up to NorthStar Bets today<\/a>!<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The San Francisco 49ers look to win their fifth straight game when they visit the Indianapolis Colts on Monday night. The pregame narrative: The 49ers are getting healthy and at the right time. They are averaging 31.0 points per game during their winning streak and have another opportunity to put up a ton of points [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":387622,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"sidebar_plugin_meta_block_field":"","footnotes":""},"categories":[61],"tags":[14,232],"class_list":["post-387612","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl","tag-nfl-betting","tag-nfl-picks"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>49ers vs. Colts picks: 2025 NFL Week 16 | The Boost<\/title>\n<meta name=\"description\" content=\"Check out our 2025 Week 16 49ers vs. Colts picks. 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