{"id":373860,"date":"2025-10-07T14:52:26","date_gmt":"2025-10-07T18:52:26","guid":{"rendered":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/?p=373860"},"modified":"2025-10-07T14:52:26","modified_gmt":"2025-10-07T18:52:26","slug":"nfl-week-6-upset-picks-and-predictions-2025","status":"publish","type":"post","link":"https:\/\/cms.northstargaming.ca\/admin\/nsgcms\/nfl-week-6-upset-picks-and-predictions-2025\/","title":{"rendered":"NFL Week 6 upset picks: Back the Detroit Lions, San Francisco 49ers to author underdog victories"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The dogs were barking in the NFL last week, and I&#8217;m looking for a pair of underdogs to keep the upsets coming in Week 6.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The pregame narrative<\/strong>: Three of the four heaviest favourites (Buffalo Bills, Arizona Cardinals, Los Angeles Rams) lost outright last week. The Philadelphia Eagles also went down as favourites, meaning no undefeated teams remain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Check out my top Week 6 NFL upset picks, featuring a best bet on the Detroit Lions against the Kansas City Chiefs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"block-0a4ee124-09d4-4260-81c9-fd6fe232dbb3\">NFL upset picks: Week 6<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"block-479767b6-5872-497b-ac44-239c07c7e3d5\"><strong>Best bet: Lions moneyline (+110)<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.northstarbets.ca\/sportsbook\/news\/nfl_bts_2025?utm_source=Insights&amp;utm_medium=text_link&amp;utm_campaign=bts_2025\">Weekly prizes &amp; bet boosts: Beat the Spread Challenge. ENTER NOW!<\/a><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit is barely an underdog in this matchup, but it&#8217;s an underdog nonetheless. And that&#8217;s shocking to me, considering how well the group has played since Week 1.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The Lions are averaging 40.3 points and 394.8 yards during their four-game winning streak.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In that span, they rank first in offensive EPA per play and second in defensive EPA per play, per RBSDM.com.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Now, the squad tests its mettle against the Chiefs at Arrowhead Stadium.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kansas City has played <em>much <\/em>better over the last three games after starting the year 0-2. But it still took a loss on Monday Night Football against the Jacksonville Jaguars, and has a suspect, if not outright bad, run defence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Chiefs&#8217; defence ranks 26th in yards per rush (4.8) and 31st in EPA per rush. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detroit loves to run the football and has two backs, Jahmyr Gibbs and David Montgomery, humming behind an elite offensive line.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I expect the Lions to win this game in the trenches and put up a gaudy amount of points yet again.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Key stat<\/strong>: Detroit has put up 30+ points in 10 of its last 11 games dating back to Week 14 of last season.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"cacheembed:118945\">Embed: #118945<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><a href=\"https:\/\/www.northstarbets.ca\/sportsbook\/sports-hub\/american_football?utm_source=insights&amp;utm_medium=text_link&amp;utm_campaign=sportsbook_nfl\">Full NFL markets<\/a><\/strong><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/www.northstarbets.ca\/sportsbook\/news\/stats\/nfl\/standingshttps:\/\/www.northstarbets.ca\/sportsbook\/news\/stats\/nfl?utm_source=insights&amp;utm_medium=text_link&amp;utm_campaign=sportsbook_nfl\">NFL player &amp; team stats<\/a><\/strong><\/li>\n\n\n\n<li><a href=\"https:\/\/www.northstarbets.ca\/sportsbook\/news\/article\/nfl-injury-report\"><strong>NFL injury report<\/strong><\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"block-fa134a48-a478-432b-95e0-66881f0d337b\">NFL underdog predictions<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>49ers moneyline (+135):<\/strong> San Francisco&#8217;s injury report has been lit up like a Christmas tree all season, but the team keeps finding ways to win ballgames. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Having last played on Thursday Night Football, I&#8217;m hoping the extra rest will help Kyle Shanahan&#8217;s squad get ready for a huge matchup against the 4-1 Tampa Bay Buccaneers. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy, Jauan Jennings and Ricky Pearsall are all questionable after missing Week 5, with the first two participating in an optional practice on Monday.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That&#8217;s something to keep an eye on as the week progresses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the other side, Mike Evans remains out for Tampa, with Bucky Irving also questionable after missing Sunday&#8217;s game.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco has relied heavily on Christian McCaffrey, its defence, and strong play-calling to this point. The Niners have won four straight games against the Bucs, and I expect that trend to continue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>NFL upset picks made at 1:10 p.m. ET on 10\/07\/2025.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The dogs were barking in the NFL last week, and I&#8217;m looking for a pair of underdogs to keep the upsets coming in Week 6. The pregame narrative: Three of the four heaviest favourites (Buffalo Bills, Arizona Cardinals, Los Angeles Rams) lost outright last week. The Philadelphia Eagles also went down as favourites, meaning no [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":373874,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"sidebar_plugin_meta_block_field":"","footnotes":""},"categories":[61],"tags":[14],"class_list":["post-373860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl","tag-nfl-betting"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NFL upset picks: 2025 Week 6 underdog predictions | NSB<\/title>\n<meta name=\"description\" content=\"Check out our 2025 Week 6 NFL upset picks. 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