This weekend is full of action from Europe’s top soccer leagues.
The pre-weekend narrative: Tottenham has the chance to stay in the top two of the EPL standings when it hosts Wolverhampton on Saturday. In La Liga, giants clash as Real Madrid visits Atletico Madrid for a marquee matchup.
Check out this weekend’s best European soccer predictions for games beginning on Sept. 27, 2025, featuring a pick on AC Milan vs. Napoli.
Soccer predictions
Tottenham vs. Wolverhampton (Sept. 27, 3 p.m. ET)
Best bet: Tottenham halftime/fulltime (+120)
Tottenham looks like a true contender this season. Now, the side hosts the worst team in the EPL.
- The Spurs sit in third on the Premier League table with a 3-1-1 record.
- They have a +7 goal differential with the third-best average match rating (7.04), per Fotmob.com.
- Wolverhampton is at the other end of the spectrum, with the worst average rating (6.36) and goal differential (-9).
It is the only team without a point in the Premier League standings, and things aren’t looking up on the road against Tottenham.
Unlike last year, it’s been Tottenham’s defence that stands out so far. The Spurs have allowed three goals in five matches.
The offence also ranks in the top four, scoring 2.0 goals per match. That’s a good foundation for a strong home performance.
Key stat: Wolverhampton’s opponents are 4-1 on this wager in the EPL this season.
La Liga best bet
Matchup: Atletico Madrid vs. Real Madrid (Sept. 21, 3:00 p.m. ET)
Real Madrid to win (+140): Even though Madrid is on the road, there’s strong value here.
Los Blancos have stormed out of the gates, picking up six straight wins with a +11 goal differential.
Atletico’s defence has been solid, but it’s struggled to score goals. The side has a measly six after six matches.
That’s not going to fly against Real Madrid, which has conceded a league-low three goals.
Xabi Alonso’s team is 3-0-0 on the road with nine goals scored.
I feel good backing Madrid going into Metropolitano Stadium and securing three points to stay perfect on the year.
Serie A prediction
Matchup: AC Milan vs. Napoli (Sept. 28, 2:45 p.m. ET)
AC Milan to win (+145): I faded Milan last week, and it was a mistake. It had no problem beating Udinese on the road.
The 3-0 thrashing was Udinese’s first loss in Serie A this season, and I expect Milan to take another zero this weekend.
- Milan started the season with a loss but has picked up three straight Serie A wins since. The side has seven goals during that time and has held clean sheets in every match.
- Massimiliano Allegri’s group then beat Serie A side Lecce, 3-0, in Coppa Italia on Sept. 23.
It’s really hard to bet against a team riding that high.
Napoli is 4-0-0, but is showing cracks.
It lost 2-0 to Manchester City in the Champions League and barely scraped by second last place Pisa, 3-2, at home. Both those matches were within the past six days.
Milan carries the momentum right now and carries the crucial advantage of playing at home.
Soccer predictions made at 1:45 p.m. on 09/24/25.
Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.