NFL Week 6 schedule, odds and betting lines: Matchups and top storylines

Injuries are starting to pile up as the NFL gets into the heart of its schedule.

The latest: CeeDee Lamb and Lamar Jackson are the two biggest names on the injury report. The Baltimore Ravens are spiralling out of control and are in desperate need of their starting quarterback. In prime time, the Kansas City Chiefs and Detroit Lions meet to headline NFL Sunday.

Check out the latest NFL Week 6 schedule below.

NFL Week 6 schedule notes

  • It’s past time to panic for the Ravens. The squad is 1-4 after a 44-10 thrashing by the Houston Texans. Baltimore has allowed 37+ points in four of five games and could be without Jackson again in Week 6. The Rams got upset by the 49ers in Week 5, but they’d have a great shot to get back in the win column if Jackson can’t suit up.
  • The next chapter of the NFL International Series is between the Broncos and Jets in London. Denver laid waste to the Eagles’ undefeated record, scoring 18 fourth-quarter points in the comeback win. The Jets are winless so far but 2-3-0 ATS.
  • How good are the Colts (4-1)? Jonathan Taylor has multiple three-TD games, and Daniel “Indianapolis” Jones is having a career resurgence with nine total touchdowns and two interceptions. They play the Cardinals (2-3) in Week 6.
  • Sunday Night Football should be an exciting one. The star-studded Lions visit Patrick Mahomes and the Chiefs. Detroit and Kansas City last met in 2023, and Jared Goff won that duel, leading his team to a narrow 21-20 win.
  • Both the Falcons and Bears will be well rested, coming off a bye to play in the doubleheader on Monday Night Football. Atlanta hosts the Bills while Chicago hits the road to take on the Commanders.

NFL Week 6 matchups: Thursday night and Sunday morning

Philadelphia Eagles vs. New York Giants

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Denver Broncos vs. New York Giants

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Sunday’s 1 p.m. slate

Arizona Cardinals vs. Indianapolis Colts

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Los Angeles Rams vs. Baltimore Ravens

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Cleveland Browns vs. Pittsburgh Steelers

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Seattle Seahawks vs. Jacksonville Jaguars

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Los Angeles Chargers vs. Miami Dolphins

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Dallas Cowboys vs. Carolina Panthers

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New England Patriots vs. New Orleans Saints

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Sunday’s 4 p.m. slate

Tennessee Titans vs. Las Vegas Raiders

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San Francisco 49ers vs. Tampa Bay Buccaneers

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Cincinnati Bengals vs. Green Bay Packers

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Sunday & Monday Night Football matchups

Detroit Lions vs. Kansas City Chiefs

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Buffalo Bills vs. Atlanta Falcons

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Chicago Bears vs. Washington Commanders

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Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.