We’re nearly a third of the way through the NFL season and are starting to get a feel for which squads are legit.
The league’s only undefeated teams (Chiefs, Vikings) are on bye but there’s no shortage of quality matchups this weekend.
Check out our Week 6 NFL betting guide, featuring staff picks and predictions to help you make the best wagers.
NFL betting guide: Week 6
The 49ers re-rook first in the NFC West with a shootout victory over the Seahawks to kick off Week 6.
There are plenty of other big games on tap, including a 1 p.m. ET banger between the Ravens and Commanders. Reigning MVP Lamar Jackson takes on rookie standout Jayden Daniels for DMV supremacy.
Later, the Lions and Cowboys battle in Jerry World before the Bills and Jets close the action with a huge Monday Night Football showdown.
Robert Saleh is out as Jets head coach and the Bills have lost two straight in embarrassing fashion. A win propels either team to the top of the division, while a loss leaves serious question marks.
Here are some quick betting notes before diving into the meat and potatoes of the slate:
- Highest total: Lions vs. Cowboys (52)
- Biggest spreads: Eagles (-9); Ravens (-7) vs. Texans (-6.5)
- Five teams have odds of +200 or longer to win (Cardinals, Browns, Patriots, Commanders, Panthers)
Lines and odds are listed as of 4:00 p.m. ET on Oct. 11. For the latest, check out our NFL Week 6 markets.
Now, see how our staff is wagering on this slate.
Week 6 betting predictions
If you need a one-stop shop for spread bets, we have you covered.
Our NFL Week 6 ATS picks, via Avery Perri, Jordan Horrobin, Spencer Closs and Chris Toman, provide a recommendation against the spread for every game.
We have plenty of other picks, too.
Underdogs: Bo Nix and the Broncos have turned things around after a tough start to the season. Read why Closs likes them to beat the Chargers plus an upset overseas.
Parlay picks: One moneyline, one ATS pick, and one over/under make up this +349 parlay headlined by two AFC North teams.
Prop picks: Daniels is on a fast track to win Offensive Rookie of the Year. Find out how Horrobin is backing him against the Ravens, plus two more prop bets.
Lions vs. Cowboys same-game parlay picks: The last time the Lions and Cowboys met, fans were treated to a thriller where CeeDee Lamb went off. Perri expects more fireworks from the wide receiver as part of this +360 wager.
TD picks: Drake London is buzzing and now gets to go up against a soft Panthers defence. That sounds like a recipe for success. Read about London and two more players.
SNF and MNF predictions
Full Sunday Night Football and Monday Night Football predictions coming soon…
Visit our football vertical for complete NFL coverage, including the latest Super Bowl odds.
NorthStar Bets is owned by NordStar Capital, which also owns Torstar, the Star's parent company. Follow them on Twitter: @NorthStarBet