You won’t find many lopsided matchups on the NFL Week 5 schedule.
The latest: The upcoming action starts with a must-see matchup between the San Francisco 49ers and Los Angeles Rams. Then, on Sunday, the Washington Commanders visit the Los Angeles Chargers before the Buffalo Bills host the New England Patriots on Sunday Night Football.
Check out the latest NFL Week 5 schedule below.
NFL Week 5 schedule notes
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- It’s early, but San Francisco and Los Angeles meet in a game that has significant divisional implications. The Rams swept the season series a year ago, but the Niners had won nine of the previous 11 before 2024.
- The Minnesota Vikings are hoping for better luck in London after the team fell short against the Pittsburgh Steelers in Dublin. Their opponent, the Cleveland Browns, is coming off a loss to the Detroit Lions.
- The Jaxson Dart era started with a bang! The rookie quarterback led the New York Giants to an upset win over the Los Angeles Chargers. Malik Nabers did leave the contest on a cart with a feared ACL injury, though. The G-Men battle the New Orleans Saints next.
- The Tampa Bay Buccaneers suffered their first loss of the season to the Philadelphia Eagles. Upcoming is a road trip to battle the Seattle Seahawks. Seattle took care of business with a win over the Arizona Cardinals on Thursday Night Football, enjoying a rest advantage ahead of this contest.
- The Buffalo Bills continue to coast through inferior opponents. The team has won by double digits in three consecutive weeks and now hosts the divisional rival New England Patriots. The Pats are coming off a convincing, 42-13 win over the Carolina Panthers.
NFL Week 5 matchups: Thursday night and Sunday morning
San Francisco 49ers vs. Los Angeles Rams
Minnesota Vikings vs. Cleveland Browns
Sunday’s 1 p.m. slate
Dallas Cowboys vs. New York Jets
Denver Broncos vs. Philadelphia Eagles
Houston Texans vs. Baltimore Ravens
New York Giants vs. New Orleans Saints
Las Vegas Raiders vs. Indianapolis Colts
Miami Dolphins vs. Carolina Panthers
Sunday’s 4 p.m. slate
Tampa Bay Buccaneers vs. Seattle Seahawks
Tennessee Titans vs. Arizona Cardinals
Washington Commanders vs. Los Angeles Chargers
Detroit Lions vs. Cincinnati Bengals
Sunday & Monday Night Football matchups
New England Patriots vs. Buffalo Bills
Kansas City Chiefs vs. Jacksonville Jaguars
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Stevie’s an avid NFL, NHL, and tennis bettor who has no problem talking himself into the underdog. His previous stops include Yahoo! Sports Canada and Toronto Metropolitan University, where he received a degree in Sport Media.