With less than two months away from the start of the 2025 NFL season, it’s never too early to check in on the Week 1 schedule and odds.
The latest: The defending-champion Philadelphia Eagles begin the season at home on Thursday, Sept. 4, against their division rival Dallas Cowboys. The crown jewel of Week 1 is on Sunday Night Football, though, as the Buffalo Bills host the Baltimore Ravens in a rematch of last year’s divisional round.
Check out the latest NFL Week 1 schedule and betting lines below.
NFL Week 1 schedule notes
- Dallas got flattened by Philadelphia in both meetings last year, losing by a combined score of 75-13. This matchup will be the first meaningful appearance for George Pickens and Javonte Williams as Cowboys, while the Eagles have nearly all the star power from last year’s Super Bowl team (including Saquon Barkley, of course).
- After 29 consecutive years without a division title, the Lions are favoured to win their third in a row this season. The main challengers in that pursuit should be the Packers, who hope rookie wideout Matthew Golden can help balance out an offence that was run-heavy for most of last year. Detroit lost both of its coordinators to head coaching positions in the offseason.
- Speaking of a former Lions coordinator, Ben Johnson will make his head coaching debut for Chicago on Monday Night Football against Minnesota. It’ll also be the NFL debut for Vikings quarterback J.J. McCarthy, who missed his entire rookie season due to a knee injury.
- The last time the Ravens stepped foot in Western New York, Mark Andrews let a game-tying 2-point conversion slip through his fingertips in the closing minutes of a playoff game. Since 2022, Buffalo is an NFL-best 25-4 at home.
- Year 2 of the Jayden Daniels show begins at home against the New York Giants, who boast a loaded pass rusher group that added Abdul Carter at the top of the 2025 draft. Overs went 13-7 in Commanders games last year, while unders were 11-6 in Giants games.
NFL Week 1 matchups: Thursday & Friday nighters
Dallas Cowboys vs. Philadelphia Eagles
Kansas City Chiefs vs. Los Angeles Chargers
Sunday’s 1 p.m. slate
Tampa Bay Buccaneers vs. Atlanta Falcons
Pittsburgh Steelers vs. New York Jets
Miami Dolphins vs. Indianapolis Colts
Carolina Panthers vs. Jacksonville Jaguars
New York Giants vs. Washington Commanders
Arizona Cardinals vs. New Orleans Saints
Cincinnati Bengals vs. Cleveland Browns
Las Vegas Raiders vs. New England Patriots
Sunday’s 4 p.m. slate
San Francisco 49ers vs. Seattle Seahawks
Tennessee Titans vs. Denver Broncos
Detroit Lions vs. Green Bay Packers
Houston Texans vs. Los Angeles Rams
Sunday & Monday Night Football matchups
Baltimore Ravens vs. Buffalo Bills
Minnesota Vikings vs. Chicago Bears
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Jordan enjoys writing data-driven game previews and analysis articles — especially for MLB markets or NFL/NBA props. And as a proud Ohio University grad, he’ll always have a soft spot for college sports (especially if the Bobcats are involved). Previous stops include mlb.com, Sportsnet and The Athletic.