The NFL’s Hall of Fame Game is in the books, and preseason Week 1 is on deck.
The latest: The Buffalo Bills’ quest for a Super Bowl starts with a preseason date against the New York Giants. The Carolina Panthers will have some familiar faces in their lineup as they battle the Cleveland Browns, a team undergoing a quarterback competition this summer.
Check out the latest NFL preseason Week 1 schedule and betting notes below.
NFL preseason Week 1 betting notes
- Indianapolis is undergoing a QB competition this offseason, and it’ll be worth monitoring Daniel Jones and Anthony Richardson’s reps versus the Baltimore Ravens. The two are fighting for the starting role to open the season.
- Cleveland’s QB battle will play out in preseason Week 1, as Joe Flacco, Kenny Pickett, Dillon Gabriel and Shedeur Sanders all compete for the starting job. Pickett and Sanders have missed time in training camp due to injury, so it’s unclear how the reps will be divvied up.
- Carolina Panthers head coach Dave Canales is playing his starters through the team’s first two preseason games, including quarterback Bryce Young. Young enters this year firmly entrenched as the starter after throwing seven touchdowns to zero interceptions in his final three games last year.
- Buffalo’s quest for a Super Bowl begins with a preseason date against the Giants. The Bills will likely rest their starters, but it’ll be worth watching New York in this contest. First-round pick Jaxson Dart will likely play his first NFL snaps in this contest.
- It’ll be interesting to see if the 2025 first overall pick, Cam Ward, receives any reps for the Tennessee Titans in their preseason game against the Tampa Bay Buccaneers. Ward has been receiving plenty of first-team reps for Tennessee in training camp.
- The New Orleans Saints have a full-fledged QB battle on their hands. Rookie Tyler Shough is competing with Spencer Rattler and Jake Haener for the job. All three will likely receive reps against the Los Angeles Chargers, and it’ll be interesting to see the order in which they enter the game.
NFL preseason Week 1 odds
Full NFL preseason Week 1 betting markets
Thursday, Aug. 7
Indianapolis Colts (-113) vs. Baltimore Ravens (-108)
Over/Under: 35
Kickoff time: 7 p.m. ET
Cincinnati Bengals (-113) vs. Philadelphia Eagles (-108)
Over/Under: 35.5
Kickoff time: 7:30 p.m. ET
Las Vegas Raiders (-104) vs. Seattle Seahawks (-118)
Over/Under: 35.5
Kickoff time: 10 p.m. ET
Friday, Aug. 8
Cleveland Browns (+118) vs. Carolina Panthers (-148)
Over/Under: 34.5
Kickoff time: 7 p.m. ET
Detroit Lions (-112) vs. Atlanta Falcons (-109)
Over/Under: 33.5
Kickoff time: 7 p.m. ET
Washington Commanders (+110) vs. New England Patriots (-134)
Over/Under: 33.5
Kickoff time: 7:30 p.m. ET
Saturday, Aug. 9
New York Giants (+115) vs. Buffalo Bills (-139)
Over/Under: 35.5
Kickoff time: 1 p.m. ET
Houston Texans (+105) vs. Minnesota Vikings (-129)
Over/Under: 36
Kickoff time: 4 p.m. ET
Dallas Cowboys (-143) vs. Los Angeles Rams (+118)
Over/Under: 33.5
Kickoff time: 7 p.m. ET
Pittsburgh Steelers (+100) vs. Jacksonville Jaguars (-122)
Over/Under: 35.5
Kickoff time: 7 p.m. ET
Tennessee Titans (-124) vs. Tampa Bay Buccaneers (+102)
Over/Under: 35
Kickoff time: 7:30 p.m. ET
Kansas City Chiefs (-129) vs. Arizona Cardinals (+106)
Over/Under: 35.5
Kickoff time: 8 p.m. ET
New York Jets (+107) vs. Green Bay Packers (-130)
Over/Under: 34.5
Kickoff time: 8 p.m. ET
Denver Broncos (-104) vs. San Francisco 49ers (-118)
Over/Under: 34
Kickoff time: 8:30 p.m. ET
Sunday, Aug. 10
Miami Dolphins (+112) vs. Chicago Bears (-137)
Over/Under: 35.5
Kickoff time: 1 p.m. ET
New Orleans Saints (-136) vs. Los Angeles Chargers (+112)
Over/Under: 35.5
Kickoff time: 4:05 p.m. ET
NFL preseason Week 1 odds as of 3:36 p.m. on 08/03/2025.
Stevie’s an avid NFL, NHL, and tennis bettor who has no problem talking himself into the underdog. His previous stops include Yahoo! Sports Canada and Toronto Metropolitan University, where he received a degree in Sport Media.