French Open quarterfinal picks and predictions: Best bets for Zverev vs. Djokovic and Keys vs. Gauff

French Open predictions

The French Open has reached the quarterfinal stage, and there’s plenty of star power left.

Today’s French Open narrative: Novak Djokovic continues to defy time with another elite performance at the French Open. But the 2023 champion has a tall task ahead of him against Alexander Zverev, the No. 3-ranked men’s player.

Check out my French Open predictions for the June 4 quarterfinal matches, featuring a pick on Coco Gauff.

French Open predictions

Best bet: Zverev/Djokovic over 41 games (-112)

These two competitors are at their highest forms right now.

  • They have combined to lose just one set at this year’s French Open.
  • Zverev does his best work on clay, recording a 206-85 record on the surface (18-6 in 2025).
  • Djokovic dwarfs that with his 223-45 on record on clay.
  • His 36-8 record on the surface since the start of 2023 proves he still has a lot of juice left at 38 years old.

These two don’t have much recent history. They’ve only completed three sets against one another since the start of 2022.

They were close, however. Two went to tie breaks (7-6), and the third finished 7-5.

This is a high total, but four close sets would still be enough to get over this mark. And it’s been a task to break either of these players, so I expect a lengthy match.

As long as both men can win at least one set, the over is very much in play for this matchup.

Key stat: Djokovic and Zverev’s last two completed matches at Grand Slam majors have gone over this mark with an average of 45.5 games played.

Go to full French Open betting markets.

Best women’s quarterfinal tennis pick

Gauff to win over 12.5 games (-112): The world’s No. 2-ranked player is making a splash at 21 years old.

She’s 28-8 in 2025 and still has the opportunity to conquer another major after winning the U.S. Open in 2023.

And it so happens that this is her best playing surface.

Gauff is 76-29 in her career on clay (15-3 this season). She’s also yet to lose a set at the French Open and has only needed one tiebreaker.

Madison Keys is no slouch, boasting a 28-6 record this year, but her 19-3 record on hard courts outweighs her 9-3 record on clay.

She has the tools to put up a decent fight against Gauff, and that’s why I’m playing this market.

If Gauff needs seven games to win any set, this pick cashes.

Plus, if Keys manages to make this close, it’ll force Gauff to need to win more than 13 games in this match, regardless of the result.

French Open predictions made at 1:42 p.m. on 06/03/2025.

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Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.