The Premier League rolls on to Matchday 2 this week with a pair of Grade-A matchups on deck.
The Week 2 narrative: Tottenham has long been a thorn in Manchester City’s side, but the Citizens are heavily favoured to win this fixture at the Etihad. The last matchup of the week takes place at St James’ Park, where reigning champion Liverpool takes on Newcastle United.
Check out the latest EPL odds for Matchday 2 below.
EPL odds and key fixtures
- Tottenham is an impressive 5-4-1 in its last 10 meetings against Manchester City, picking up a shocking 4-0 win at the Etihad last season. City won the reverse fixture, 1-0, at Tottenham Stadium, though, and is the prohibitive favourite to win this matchup.
- The Thomas Frank EPL era began with a 3-0 win for Spurs after a solid showing in the European Super Cup against PSG (2-2 loss in penalties). City also picked up a clean sheet win, smashing Wolverhampton, 4-0, behind an Erling Haaland brace.
- Liverpool was level with Bournemouth heading into the dying minutes of Matchday 1 before Federico Chiesa broke the deadlock with an 88th-minute goal at Anfield.
- The Reds lost their last fixture against Newcastle, 2-1, in the 2025 League Cup, snapping a 17-game unbeaten streak against the Magpies.
- Newcastle went 12-2-5 at home last year, drawing Liverpool 3-3 in their meeting at St James’ Park.
EPL Matchday 2 betting lines
West Ham (+410) vs. Chelsea (-148)
Aug. 22 3:00 p.m. ET
Bournemouth (-122) vs. Wolves (+335)
Aug. 23 7:30 a.m. ET
Brentford (+235) vs. Aston Villa (+118)
Aug. 23 10:00 a.m. ET
Burnley (+145) vs. Sunderland (+220)
Aug. 23 10:00 a.m. ET
Arsenal (-360) vs. Leeds United (+1,050)
Aug. 23 12:30 p.m. ET
Crystal Palace (+130) vs. Nottingham Forest (+225)
Aug. 24 9:00 a.m. ET
Everton (+200) vs. Brighton (+148)
Aug. 24 9:00 a.m. ET
Fulham (+235) vs. Manchester United (+120)
Aug. 24 11:30 a.m. ET
- Chelsea has dominated its derby matchup against West Ham in recent years, going 7-2-1 in the last 10 matchups. That includes a pair of wins last season by a combined score of 5-1.
- Arsenal eked out a 1-0 win over Manchester United on Matchday 1 but should have no problem smashing newly-promoted Leeds United at the Emirates. The Gunners went 11-6-2 at home last season.
- Speaking of the Red Devils, they probably deserved a better result after generating 1.5 xG to Arsenal’s 1.3. Ruben Amorim’s side has a chance to get in the win column against a Fulham squad it beat twice in the EPL last season (both matches ended 1-0).
EPL odds as of 10:55 a.m. ET on 08/19/2025.
Avery joined NorthStar Gaming as an intern in 2022 before stepping into a full-time role soon after. He loves betting on and analyzing golf — mainly because it’s easier than actually playing — but is a fan of all sports, from the NFL to the UFC.