A pair of AFC division leaders will clash at SoFi Stadium this week, as the Los Angeles Chargers host the Indianapolis Colts.
The pregame narrative: Indianapolis hasn’t faced many true tests yet, so it’s too early to know if the 5-1 start is legit. But we all know that Jonathan Taylor is the real deal, as he leads the league in rushing yards (603) and touchdowns (seven).
Check out my Colts vs. Chargers +335 same-game parlay predictions for Week 7, featuring Taylor and Kimani Vidal.
Colts vs. Chargers SGP predictions
SGP: Vidal over 55.5 rush yards | Taylor anytime TD | Colts +7.5 (+335)
Vidal over 55.5 rush yards (-113): After the injuries to Najee Harris and Omarion Hampton, it was anybody’s guess how the Chargers would deploy their inexperienced and unproven backfield.
Well, at least for one week, the answer was to give the ball to Vidal a bunch of times and watch him work.
Vidal saw the lion’s share of snaps (67%) and carries (18) for the Chargers, turning that into 124 yards on the ground.
In contrast, Hassan Haskins had a 31% snap share and generated 14 yards on six rush attempts.
The sample size is merely one week, so there’s no guarantee that the Chargers are just handing the RB1 job to Vidal, a sixth-round pick from a year ago. But if you’re buying in on his opportunity, this line likes pretty low.
Obviously, Vidal smashed this number last week. And now he’ll face a Colts defence that has been mediocre against the run.
Indianapolis has allowed 4.3 yards per rush, which ranks 18th in the NFL. More notably, perhaps, is that Indy’s defence ranks 31st in run success rate (48.0%), per RBSDM.com.
More SGP picks
Taylor anytime TD (-190): Taylor has been a beast all season, and he’s been cashing in on plenty of scoring chances lately.
- In his past four games, Taylor has seven TDs.
- He has scored a touchdown in four of his past five games.
- Taylor has 20+ touches in all six games. And he has 5+ red zone touches in five of six.
Not all red zone touches are created equal, but Taylor is seeing tons of Grade-A opportunities. He has 11 carries inside the five-yard line over the past four weeks.
The Chargers have a solid defence, but I like Taylor’s chances of scoring against basically any team right now.
Colts +7.5 (-360): Are the Colts (5-1 SU, 4-2 ATS) for real? I still don’t know. But I’m comfortable buying enough points with them to get the underdog spread north of a touchdown.
Indy has covered this number in every game this season. And its +78 point differential is more than twice as good as any other AFC team.
The Chargers have had a shaky handful of weeks, going 0-3-1 ATS since Sept. 21. They were favoured in all of those games.
L.A. has only covered this number once this season, and that was in a 20-9 win over the Raiders. Three weeks later, Indy beat that same Raiders team, 40-6.
Colts vs. Chargers predictions made at 1:19 p.m. ET on 10/17/2025.
Jordan enjoys writing data-driven game previews and analysis articles — especially for MLB markets or NFL/NBA props. And as a proud Ohio University grad, he’ll always have a soft spot for college sports (especially if the Bobcats are involved). Previous stops include mlb.com, Sportsnet and The Athletic.