Champions League picks and predictions Nov. 4: Back Arsenal to dominate, Real Madrid to defeat Liverpool

Champions League predictions Nov. 4

Two European giants, Liverpool and Real Madrid, headline Tuesday’s crop of Champions League fixtures.

The pregame narrative: Liverpool is not in form right now. That can be detrimental when hosting a team of Madrid’s calibre. Earlier on, look for Arsenal to dominate Czech side Slavia Prague.

Check out the best Champions League predictions for the matches on Nov. 4.

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Champions League predictions

Best bet: Arsenal half time/full time (-141)

This bet cashes if the team leads at half and after 90 minutes. Arsenal has a solid shot to do just that with how it’s been rolling.

  • The Gunners are in first place in the Premier League with a six-point cushion over second-place Manchester City.
  • The side is 3-0-0 in the Champions League without conceding to this point.

Defence has been a strong point all season, as Arsenal has allowed just three goals in 13 matches, including both the EPL and UCL.

That gives the side an extremely high floor against these lower-tier opponents. If Arsenal grabs an early lead, chances are it’s not giving it back.

-> Bet on Arsenal to win

And that’s the case in this match. Slavia Prague is winless in three Champions League fixtures with two goals scored and a -3 goal differential.

When Prague had to play another top side (Inter Milan), it lost 3-0 and after conceding a pair of first-half goals. Inter had 21 shots compared to Prague’s two, dominating from start to finish.

I expect a very similar effort from the Gunners, who should control every aspect of this match.

Key stat: Arsenal have the third-best average match rating in the UCL league phase, per Fotmob (7.39).

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Best bet: Liverpool vs. Real Madrid

Real Madrid to win (+165): I simply cannot back Liverpool as the favourite in this matchup with how the side has been playing.

  • After starting the season 6-0-0 across all competitions, the Reds have lost five of the past seven.
  • The former EPL favourites dropped to third in the standings and are now seven points back of Arsenal.

On the other hand, Real Madrid is white-hot. Los Blancos have won six straight, including a 1-0 victory over Juventus in the UCL.

It was almost impossible to fade Liverpool last year, but this season has been off to a rough start, and Madrid has the firepower to hand the Reds another loss.

Real Madrid has the best average match rating (7.52) and ranks inside the top three for shots on goal, expected goals for and goals conceded per match.

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Matchday 4 schedule: Nov. 4

Tuesday’s fixtures (12:45 p.m. ET)

  • Napoli vs. Frankfurt
  • Slavia Prague vs. Arsenal

Tuesday’s fixtures (3:00 p.m. ET)

  • Atletico Madrid vs. Union Saint-Gilloise
  • Glimt vs. AS Monaco
  • Juventus vs. Lisbon
  • Union Saint-Gilloise vs. Inter Milan
  • Liverpool vs. Real Madrid
  • Olympiakos vs. PSV

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Champions League predictions made at 1:45 p.m. on 11/3/2025.

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Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.