The Monday Night Football doubleheader opens with the Buffalo Bills visiting the Atlanta Falcons.
The pregame narrative: The Bills are coming off their first loss of the year, while Atlanta is fresh off its bye week. Buffalo is expected to bounce back as a 4-point favourite, but I believe the Falcons can keep this game close or even win straight up.
Check out my Bills vs. Falcons same-game parlay predictions for Week 6, featuring Drake London and James Cook.
Bills vs. Falcons SGP predictions
SGP: Falcons +7.5 | London 6+ receptions | Cook anytime TD (+340)
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Falcons +7.5 (-205): Atlanta’s 30-0 loss against the Carolina Panthers in Week 3 stands out like a sore thumb.
Other than that, the squad has looked competitive in every game to begin the season.
- In Week 1, the Falcons lost to the Tampa Bay Buccaneers, 23-20. Tampa looks like a contender at 4-1.
- In Week 2, Atlanta bounced back to trounce the Minnesota Vikings, 22-6.
- Before the bye, the Falcons scored a season-high 34 points in a seven-point win over the Washington Commanders.
That makes them 3-1 against this spread, so I’m willing to chalk up that Panthers loss as an outlier.
Buffalo has been as good as advertised at a base level, holding a 4-1 record. However, the Bills haven’t been super dominant against a pretty weak schedule.
In hindsight, scoring 41 points against Baltimore isn’t as impressive as it originally looked. The Bills also have wins over the 0-6 New York Jets, the 1-4 Miami Dolphins and the 1-4 New Orleans Saints.
The Bills are 0-3 ATS in their past three games, so backing the Falcons to cover a touchdown seems like a logical choice.
Monday Night Football SGP picks
London 6+ receptions (-157): London is the alpha receiver on this offence, and he should continue to see a lot of looks from Michael Penix Jr.
Here are a few reasons why:
- His 28.46% target share ranks 12th in the NFL.
- London has been targeted 10+ times in two different games this season.
- He’s coming off an eight-catch performance against the Commanders.
The WR2 in this offence, Darnell Mooney, is once again out of the lineup this week, which should add more work to London’s plate.
In Week 5, Buffalo allowed Stefon Diggs to have a breakout game with his new team. The Patriots’ receiver hauled in 10 of his 12 targets for 146 yards.
Cook anytime TD (-150): The Bills running back is going under the radar, but he’s having another incredible season.
- Cook led the NFL with 16 rushing touchdowns last season. That’s super impressive considering Josh Allen’s involvement in the run game.
- Cook’s success has carried over into the new year. He’s scored five TDs in five games and is 4-1 against this line.
I’m expecting the Falcons to keep this one close, but I’d be a fool to think Buffalo isn’t going to have its fair share of scoring opportunities.
And that’s where Cook shines. He has 20 red zone carries, leading to four of his scores. Only Josh Jacobs, Jahmyr Gibbs and Jonathan Taylor have more red zone carries.
Atlanta allows the fewest passing yards per game, so it would make sense for Sean McDermott to try his hand with the run game early.
Bills vs. Falcons predictions made at 11:40 a.m. on 10/12/2025.
Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.