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This week’s NFL slate is loaded with great matchups.

Week 6 at a glance: Two-thirds of the games on tap have a spread under a touchdown, so fans should be treated to nail-biting action. That includes a Sunday Night Football showdown between the Detroit Lions and Kansas City Chiefs, and both games on Monday Night Football’s doubleheader.

Check out our Week 6 NFL betting guide for staff picks and predictions on the loaded 15-game slate.

NFL betting guide

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Key storylines:

• No undefeated teams remain in the NFL after the Buffalo Bills and Philadelphia Eagles went down last week. It was a big week for upsets across the board, with three of the four biggest underdogs (San Francisco 49ers, Tennessee Titans, New England Patriots) winning outright.

• The Baltimore Ravens are on the ropes after a 1-4 start. They’re 7.5-point home underdogs against the Los Angeles Rams with reigning MVP Lamar Jackson on the shelf. Somehow, Baltimore is still favoured to win the AFC North.

• Joe Flacco is on the move — again. The 40-year-old veteran was traded to the Cincinnati Bengals, who are praying to get their offence back on track after losing Joe Burrow to a foot injury in Week 2.

• Detroit is the hottest team in football, averaging north of 40 PPG during its four-game winning streak. The Lions are underdogs at Arrowhead Stadium in prime time and can send the Chiefs into uncharted waters (2-4 start) with a win.

• Daniel Jones’ hot start has become impossible to ignore. The seventh-year QB has led the Indianapolis Colts to a 4-1 record, ranking first in QBR (79.7) and third in passing yards (1,290). Indy is a 7.5-point favourite against the Arizona Cardinals in Week 6.

• Only two teams are on bye this week, the Minnesota Vikings and Houston Texans.

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NFL Week 6 betting notes

• Starting Los Angeles Chargers running back Omarion Hampton was sent to the injured reserve last week. That leaves a tandem backfield of Hassan Haskins and Kimani Vidal, with Najee Harris already sidelined. One of them should pop off against a Miami Dolphins defence ranking last in rushing yards per game.

• The Cleveland Browns have lost 21 straight regular-season games in Pittsburgh. And they’ll be travelling back from London to take on a Pittsburgh Steelers team fresh off a bye. Mike Tomlin is 16-1 SU against rookie quarterbacks at home since he joined Pittsburgh in 2007.

• The Green Bay Packers are the largest favourites on the board (14.5 points) against Flacco and the Bengals. Cincinnati is averaging fewer than 20 PPG in the 19 games Burrow has missed with an injury, and has a -76 point differential over the last two weeks.

• Can Buffalo get right on Monday Night Football against the Atlanta Falcons? The Bills are 13-3 SU on the road (or a neutral site) following a loss with Josh Allen. They’ve won those games by an average of 9.9 points.

• The NFC has had the upper hand on the AFC this year, going 18-9 ATS in its 27 cross-conference games.

Biggest spreads: Bengals vs. Packers (-14.5); Rams (-7.5) vs. Ravens; Cardinals vs. Colts (-7.5)

Highest totals: Lions vs. Chiefs (52.5); Bills vs. Falcons (50); Cowboys vs. Panthers (49.5)

NFL betting guide: Week 6 predictions

ATS picks: Get ATS predictions for the entire slate, headlined by Lions vs. Chiefs on Sunday Night Football.

Week 6 prop picks: Neither Ladd McConkey nor Davante Adams has put up WR1-level production on their respective teams, but that doesn’t mean they should be overlooked in the prop market. And Christian McCaffrey has been more active as a receiver than either of them.

Upset picks: Perri is backing a pair of 4-1 teams (Lions, 49ers) to come through as underdogs. Click the link to find out why.

Best bets: Justin Fields headlines this four-pack of NFL best bets, which includes two ATS picks and a moneyline wager.

NFL TD picks: One wide receiver, one running back, and a tight end contribute to this week’s TD picks. See who our staff is betting on to find the end zone.

Lions vs. Chiefs SNF picks: An electric matchup headlines Sunday’s slate. Click the link to find two picks for Lions vs. Chiefs on Sunday Night Football.

Lions vs. Chiefs SNF SGP: Perri is expecting Detroit to run all over Kansas City, with Jahmyr Gibbs leading the charge. Patrick Mahomes also factors into this +310 same-game parlay.

Lions vs. Chiefs SNF TD picks: Amon-Ra St. Brown is the most hyper-targeted NFL receiver in the red zone. And yet he’s still getting plus-money odds to score in prime time. Read more about why that play is worth exploring.

Monday Night Football guide

Bills vs. Falcons MNF picks: James Cook is having an incredible season for Buffalo. Click the link for a prop on the running back, plus one more prediction for Monday Night Football.

Bills vs. Falcons MNF SGP: Drake London is seeing massive target share from Michael Penix, and that should continue under the bright lights of a MNF doubleheader.

Bears vs. Commanders MNF picks: The second half of the doubleheader is highlighted by the top two picks from the 2024 draft. See why Caleb Williams and DJ Moore should connect often on Monday.

Bears vs. Commanders MNF SGP: This +410 parlay includes a pick on Jacory Croskey-Merritt. He rumbled for 111 yards in Week 5, and Horrobin is expecting another big performance out of the rookie.

NFL Week 6 matchups

Thursday Night Football (Oct. 9)

• Eagles vs. Giants (8:15 p.m. ET)

Bet on Week 6 NFL action

International Series game in London (Oct. 12)

• Broncos vs. Jets (9:30 a.m. ET)

Sunday, Oct. 12: 1 p.m. ET slate

• Cowboys vs. Panthers | Browns vs. Steelers

• Rams vs. Ravens | Chargers vs. Dolphins

• Seahawks vs. Jaguars | Patriots vs. Saints | Cardinals vs. Colts

Sunday, Oct. 12: 4 p.m. ET slate

• 49ers vs. Buccaneers | Bengals vs. Packers | Titans vs. Raiders

Sunday Night Football

• Lions vs. Chiefs (8:20 p.m. ET)

Monday Night Football double header (Oct. 13)

• Bills vs. Falcons (7:15 p.m. ET)

• Bearts vs. Commanders (8:15 p.m. ET)

Coming off a weekend full of upset wins, our staff has ATS picks for every game in NFL Week 6.

The Week 6 narrative: The Buffalo Bills and Philadelphia Eagles both suffered their first losses in Week 5, leaving no undefeated teams remaining. With five teams favoured by a touchdown or more in Week 6, the dogs could be barking once again. The Green Bay Packers are the biggest favourites this week over the downtrodden Cincinnati Bengals.

Check out our staff’s Week 6 NFL ATS picks for predictions on every game.

NFL ATS picks: Week 6

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NorthStar Bets’ Avery Perri, Jordan Horrobin, Spencer Closs, Chris Toman and Steven Psihogios offer up their Week 6 NFL ATS picks for all 15 games.

NFL odds as of 10 a.m. ET on Thursday, Oct. 9, 2025.

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Thursday Night Football pick

Eagles vs. Giants (Thursday, Oct. 9: 8:15 p.m. ET)

NorthStar Bets line: Eagles -7.5
Horrobin says: Philadelphia hasn’t covered this number yet, thanks in large part to an out-of-sync offence that ranks 30th in total yards. A week after taking six sacks, the Eagles will play without three-time Pro Bowl guard Landon Dickerson, which isn’t ideal. The Giants won outright as 6-point underdogs vs. the Chargers when they last played at home.

Staff picks: Perri (PHI) | Horrobin (NYG) | Closs (NYG) | Toman (PHI) | Psihogios (PHI)

Sunday morning NFL London pick

Broncos vs. Jets (Sunday, Oct. 12: 9:30 a.m. ET)

NorthStar Bets line: Broncos -7.5
Closs says: Denver’s been a roller coaster to start the year, but is fresh off a huge win over the Eagles. The defence is legit, and the offence is good enough to expose the Jets. New York has conceded 27+ points in all five games. The Broncos should be able to move the ball at will while holding Justin Fields and the Jets’ offence in check.

Staff picks: Perri (NYJ) | Horrobin (DEN) | Closs (DEN) | Toman (DEN) | Psihogios (DEN)

NFL ATS picks: The early Sunday slate

Cardinals vs. Colts (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Colts -7
Horrobin says: The vibes should be on the floor for the Cardinals after they were outscored 16-0 in the fourth quarter last week to lose to the woeful Titans … at home. Arizona is 1-3 ATS and SU in its past four games and just doesn’t seem to have the scoring upside that Indy (4-1 ATS) has. The Cardinals are averaging 20.6 PPG, while the Colts have scored 29+ points in four of five.

Staff picks: Perri (IND) | Horrobin (IND) | Closs (ARI) Toman (ARI) | Psihogios (IND)

Browns vs. Steelers (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Steelers -5.5
Perri says: Pittsburgh is coming off a bye week while Cleveland is returning from London to play its third game in a wildly different time zone. That doesn’t seem fair now, does it? The Browns’ offence is awful, ranking last in PPG and bottom-five in EPA per play and pressure rate allowed. I don’t think that unit can figure it out against a well-rested Steelers defence.

Staff picks: Perri (PIT) | Horrobin (PIT) | Closs (PIT) | Toman (PIT) | Psihogios (PIT)

Cowboys vs. Panthers (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Cowboys -3
Perri says: It’s time we recognize Dallas’ offence as one of the best in football. The Cowboys are averaging 30.2 PPG, sit third in EPA per play, and rank top-10 in both pass block and rush block win rate. Their defence can’t stop a nose bleed, which is a problem, but the Panthers don’t put up enough points to worry me. I think Dallas wins this game by multiple scores.

Staff picks: Perri (DAL) | Horrobin (DAL) | Closs (DAL) | Toman (DAL) | Psihogios (CAR)

Bet on NFL Week 6

Chargers vs. Dolphins (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Chargers -4
Toman says: The Chargers are banged up and in need of a bounce back following two bad losses in a row. Well, they’ve found their match in the 1-4 Dolphins, whose only victory came against the winless Jets. Miami is without playmaker Tyreek Hill, has lost three of its four games by more than this number, and is comfortably one of the worst defensive teams in the NFL.

Staff picks: Perri (MIA) | Horrobin (LAC) | Closs (LAC) | Toman (LAC) | Psihogios (MIA)

Rams vs. Ravens (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Rams -7.5
Perri says: This has blowout written all over it. Los Angeles has a rest advantage last playing on TNF. It will be eager to get back in the win column and flex its offensive muscles against Baltimore’s horrid defence. The Ravens have allowed a league-worst 35.4 PPG and don’t have Lamar Jackson to bail them out on the other end. This is a big number for a road team, but a justified one.

Staff picks: Perri (LAR) | Horrobin (LAR) | Closs (LAR) | Toman (BAL) | Psihogios (LAR)

Seahawks vs. Jaguars (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Jaguars -1
Horrobin says: Jacksonville stumbled its way — literally — into a home victory over the Chiefs last week despite getting outgained by 150+ yards and losing the turnover battle. Up next is a Seattle team with an extra day of rest and a glistening road record. The Seahawks, whose +41 point differential is the fourth-best in the NFL, are 9-1 as visitors since the start of last season.

Staff picks: Perri (SEA) | Horrobin (SEA) | Closs (SEA) | Toman (SEA) | Psihogios (SEA)

49ers vs. Buccaneers (Sunday, Oct. 12: 1 p.m. ET)

NorthStar Bets line: Buccaneers -3
Closs says: Tampa Bay has all the makings of an elite team. It is 4-1 this season with the lone loss coming against the Eagles. But the difference in that game was a blocked field goal that was returned for a Philly TD. San Francisco upset the Rams in Week 5 to reach 4-1, but the foundation is cracking. Both Mac Jones and Brock Purdy are questionable for Sunday, as well as receivers Jauan Jennings and Ricky Pearsall. Tampa’s offence is more reliable, scoring 27.0 PPG. It should be difficult for San Fran to keep pace with so many offensive pieces missing practice.

Staff picks: Perri (SF) | Horrobin (SF) | Closs (TB) | Toman (SF) | Psihogios (SF)

NFL 4 p.m. slate

Titans vs. Raiders (Sunday, Oct. 12: 4:05 p.m. ET)

NorthStar Bets line: Raiders -4.5
Closs says: Even after their first win, I don’t have any faith in the Titans. They needed an all-time choke job from the Cardinals for their one-point win in Week 5. The Raiders haven’t yielded much better results, but the squad has played five potential playoff teams to start the season. They are searching for their first win since Week 1 and have a soft landing spot against arguably the league’s worst team. Tennessee has the second-worst average scoring margin in the NFL (-13.6).

Staff picks: Perri (LV) | Horrobin (LV) | Closs (LV) | Toman (TEN) | Psihogios (LV)

Place your bets on the 4 p.m. NFL slate

Bengals vs. Packers (Sunday, Oct. 12: 4:25 p.m. ET)

NorthStar Bets line: Packers -14.5
Toman says: This should have been a marquee Week 6 matchup. But with Joe Burrow sidelined, it’s instead a cakewalk for the home Packers, who are rested coming out of their bye. Cincinnati (1-4 ATS) has lost its last three games by 13, 25 and 38 points. Despite the hefty spread, I have no concern backing Green Bay as a monster double-digit favourite.

Staff picks: Perri (GB) | Horrobin (CIN) | Closs (GB) | Toman (GB) | Psihogios (CIN)

Patriots vs. Saints (Sunday, Oct. 12: 4:25 p.m. ET)

NorthStar Bets line: Patriots -3.5
Closs says: I am bullish on New England. The Pats have a stud in Drake Maye, whose 107.8 passer rating ranks sixth in the NFL. They are 3-2 and coming off a huge win on the road over the Bills. New Orleans beat the Giants in Week 5, but were down 14-3 at halftime before three turnovers from Jaxon Dart in the second half. Altogether, the Giants turned the ball over five times, and the Saints still only managed 26 points.

Staff picks: Perri (NO) | Horrobin (NE) | Closs (NE) | Toman (NO) | Psihogios (NE)

Sunday and Monday Night NFL ATS picks

Lions vs. Chiefs (Sunday, Oct. 12: 8:20 p.m. ET)

NorthStar Bets line: Chiefs -2.5
Perri says: This feels like a trap line to me, but I’ll bite. Detroit has been picking teams apart during its four-game winning streak, averaging north of 40 points and 390 yards per game. During that run, the Lions rank first in offensive EPA per play and second in defensive EPA per play. Kansas City has two wins against teams with a combined 2-8 record. Give me Detroit all day.

Staff picks: Perri (DET) | Horrobin (DET) | Closs (DET) | Toman (KC) | Psihogios (DET)

Bet on Sunday Night Football

Bills vs. Falcons (Monday, Oct. 13: 7:15 p.m. ET)

NorthStar Bets line: Bills -4.5
Horrobin says: It’s easy to remember Atlanta’s 30-0 loss in Carolina and assume this is a bad football team. But the Falcons have covered this number in each of their other three games, including a 16-point win as underdogs in Minnesota. This will be the Bills’ first time playing outside the tri-state area, and they’re facing a squad that’s fresh off a bye.

Staff picks: Perri (BUF) | Horrobin (ATL) | Closs (ATL) | Toman (BUF) | Psihogios (BUF)

Bears vs. Commanders (Monday, Oct. 13: 8:15 p.m. ET)

NorthStar Bets line: Commanders -4.5
Perri says: The 2024 No. 1 and 2 picks square off in this matchup, and I’m leaning with Jayden Daniels and the Commanders. Washington just laid a beating on the Los Angeles Chargers, sacking Justin Herbert four times while rushing for 163 yards at 5.8 per carry. Chicago has a middling offensive line and a poor rush defence, and I think the Commanders can succeed in both aspects again.

Staff picks: Perri (WSH) | Horrobin (CHI) | Closs (WSH) | Toman (CHI) | Psihogios (CHI)

NFL ATS picks: Week 5 + season records: Toman: 7-7 (39-39) | Perri: 10-4 (37-41) | Horrobin: 7-7 (33-45) | Psihogios: 6-8 (36-42) | Closs: 7-7 (38-40)