The third and final NFL game from London kicks off this Sunday morning, and that matchup is one of the focuses of our staff’s Week 7 best bets.
The Week 7 narrative: With Puka Nacua nursing an injury, the Los Angeles Rams could lean harder on running back Kyren Williams to produce across the pond. In addition to a Williams prop bet, our staff has a pair of ATS picks and an over/under prediction.
Check out our NFL Week 7 staff best bets for our favourite picks this weekend.
NFL Week 7 best bets
These NFL Week 7 best bets were provided by NorthStar Bets writers Spencer Closs, Avery Perri and Jordan Horrobin.
ATS picks
Falcons +2.5 (-112): Atlanta’s 30-0 loss to the Carolina Panthers stands out, but there’s a lot to like from its other games.
- The Falcons beat the Buffalo Bills and Washington Commanders in back-to-back weeks, each by 7+ points.
- Atlanta also has a 16-point win over the Minnesota Vikings on the road and a three-point loss to the Tampa Bay Buccaneers (5-1).
The defence has been exceptional, holding opponents to the fewest passing yards (139.4/game) and total yards (270.4/game).
San Francisco is 4-2 but once again faces many injury concerns in Week 7. Both quarterbacks, Mac Jones and Brock Purdy, are questionable, while George Kittle remains on the injured reserve and wideout Ricky Pearsall hasn’t played since Week 4.
I know what I’m getting with the Falcons right now: an elite defence paired with a dangerous run game spearheaded by Bijan Robinson.
I’m officially putting an upset watch down for Sunday Night Football.
-Closs
Chiefs -12 (-112): It seems like Kansas City is all the way back.
Fresh off a 13-point home win over a talented Detroit Lions squad, the Chiefs — now featuring the reinstated Rashee Rice — should be able to cover this number against the lowly Raiders.
Las Vegas was outscored 81-30 in its past two road games (at Colts, at Commanders) and is 1-4 ATS in its past five. Beating the Tennessee Titans last week didn’t score a lot of points in my book.
KC has covered a -12 spread in three of its past four games and is once again the favourite in the AFC West. I expect Patrick Mahomes and Co. to act like it.
-Horrobin
Over/Under bet
Vikings/Eagles under 43.5 points (-112): It’s not sunny in Philadelphia for the defending champs right now.
The Eagles have lost consecutive games and are coming off an embarrassing primetime loss against the New York Giants.
Kevin Patullo seems rudderless in his first season as offensive coordinator, and I can’t picture him devising a solid game plan against Brian Flores’ defence.
- Philadelphia is averaging the third-fewest yards per game (274.5) and ranks 19th in EPA per play, according to RBSDM.com.
- Saquon Barkley has failed to crack 50 rushing yards in four of his last five games and is averaging just 3.4 YPC.
- A.J. Brown is averaging 45.6 receiving yards per game and has just one touchdown.
Philadelphia’s defence has also underperformed, but I like its chances of stopping either J.J. McCarthy (questionable) or Carson Wentz.
The Vikings are averaging 18.75 PPG outside of a 48-10 rout of the Bengals, where they had five turnovers and scored two defensive TDs.
-Perri
NFL Week 7 best bets: Player props
Williams over 69.5 rushing yards (-113): Puka Nacua (ankle) hasn’t practiced all week, and it seems unlikely that the star wide receiver will suit up in London.
That should mean L.A.’s offence will run through Williams, who has quite a reliable floor:
- 13+ carries in every game
- 65+ rush yards in five of six games
- 4.4 yards per carry
The Rams rank eighth in run block win rate (73%), per ESPN.com. The Jaguars, meanwhile, rank 27th in run stop win rate (28%).
I trust Sean McVay will find a way to exploit that mismatch.
-Perri
NFL Week 7 best bets made at 10 a.m. ET on 10/16/2025.
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