Chiefs vs. Giants Week 3 Sunday Night Football picks: Expect Patrick Mahomes to shine

Chiefs vs. Giants picks

The Kansas City Chiefs are still looking for their first win ahead of Sunday night’s Week 3 clash vs. the New York Giants.

The pregame narrative: New York is also winless, but was a part of an early contender for game of the year last week vs. the Dallas Cowboys. Kansas City has played tough opponents and can’t afford a loss in Week 3.

Check out my Chiefs vs. Giants picks for the Sunday Night Football matchup on Sept. 21, featuring Patrick Mahomes and Cam Skattebo.

Chiefs vs. Giants picks

Best bet: Mahomes over 34.5 pass attempts (-130)

Mahomes smashed this line in Week 1, throwing 39 passes in a loss to the Los Angeles Chargers.

Last Sunday provided a tougher matchup with the Philadelphia Eagles, and Mahomes understandably fell four attempts shy of this mark.

But the Giants are a good team to bounce back against.

  • In last week’s thriller with the Cowboys, Dak Prescott attempted 52 passes and cashed this wager well before overtime started.
  • Last season, Mahomes went 11-5 against this line and finished with 33 attempts in another game.

Another reason to like this wager is that the Chiefs can’t get anything going in the run game. Isiah Pacheco and Kareem Hunt have combined for 3.4 yards per carry on 28 rushes this season.

For context, Mahomes has more rushing yards so far than both running backs combined.

That should force the star quarterback into more passing situations.

Key stat: Since the start of the 2021 season, Mahomes is averaging 37.5 pass attempts per game.

Sunday Night Football prop pick

Skattebo over 34.5 rushing yards (-118): The Giants’ rookie back should continue getting more opportunities as the weeks go on.

Skattebo was rumbling last week with 45 yards on 11 carries. The really impressive part is that he averaged 3.18 yards after contact.

Any coach will love a hard runner, and the takeover has officially begun.

  • In Week 1, Skattebo played 12% of the Giants’ snaps and had just two rushing attempts.
  • In Week 2, he led New York’s backfield with a 52% snap share.

After the way he performed last Sunday, there’s no way Brian Daboll can do anything but give his rookie more touches.

The Chiefs have allowed running backs on both the Chargers and Eagles to top this line, and my money’s on Skattebo doing so for the Giants.

Chiefs vs. Giants picks made at 3:38 p.m. ET 09/19/2025.

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Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.