The playoff picture is starting to take shape as the CFL season rolls into Week 16.
This week’s CFL narrative: The Hamilton Tiger-Cats aim to improve on their position as East Division leaders when they play the Edmonton Elks. Before that, the Ottawa Redblacks and Winnipeg Blue Bombers face off in what should be a high-scoring contest.
Check out the latest CFL Week 16 predictions for the games beginning Friday, Sept. 19.
CFL Week 16 predictions
Best bet: Tiger-cats -5.5 (-115)
The Elks are making a sneaky push for the postseason right now, but playing on the road in Hamilton is a tough task for any team.
Plus, Edmonton hasn’t been great away from home this season.
- The Elks are 3-3 at home and 2-5 on the road.
- In those five defeats, they have an average point differential of -11.
- When these two sides met earlier this year in Edmonton, the Ti-Cats managed a four-point win.
When the Elks played the 8-4 Calgary Stampeders on the road in Week 13, Calgary dominated, winning 28-7.
The Tiger-Cats are the only team above .500 in the East (8-5), and they are on a two-game win streak.
They covered this spread in five of their eight wins this season.
Key stat: Hamilton is one of two CFL teams to average over 30 points per game on offence (30.1).
CFL Week 16 picks
Redblacks/Blue Bombers over 51.5 points (-110): Brown remains out for the Redblacks, but the offence is coming alive.
- Week 14: 34-33 win, 413 yards on offence
- Week 15: 38-27 loss, 399 yards on offence
During that time, backup quarterback Dustin Crum has flourished, completing 54 of 67 passes (80.6%) for 608 yards, two touchdowns and no interceptions.
That level of play gives Ottawa’s offence a high ceiling each week. He should be able to replicate that success against Winnipeg’s defence, which allows 27.1 points per game.
The Blue Bombers should also be able to make a significant contribution to this total. Ottawa has the second-worst defence in the league (29.7 PPG).
The Redblacks have allowed 30+ points in four straight games.
CFL betting odds and matchups: Sept. 19
Alouettes (-315) vs. Argonauts (+255)
Friday, Sept. 19, 7 p.m. ET
- Montreal lost five straight games before rebounding nicely against the league-leading Saskatchewan Roughriders in Week 15. The Alouettes dominated on the road with a 48-31 victory and look for a second consecutive road win when they play the Argonauts in Week 16.
Lions (+200) vs. Stampeders (-250)
Friday, Sept. 19, 9:30 p.m. ET
- The Lions are one of the more exciting teams in the CFL with Nathan Rourke healthy. BC has scored 30 or more points in six straight games. The negative is that the Lions have the second-worst defence in the CFL (29.6 PPG). On the other side, Calgary relies on defence, allowing a CFL low of 20.4 points per game.
CFL Week 16 predictions as of 9:16 a.m. on 09/18/2025.
Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.