French Open men’s semifinal picks and predictions: Best bets for Musetti vs. Alcaraz, Sinner vs. Djokovic

French Open predictions

The French Open men’s semifinal is filled with star power as the title at Roland Garros is up for grabs.

Today’s French Open narrative: Jannik Sinner has yet to lose a set at this event with his sights on another Grand Slam title. Novak Djokovic stands in his way and has been just as impressive at this year’s French Open.

Check out my French Open predictions for the June 6 semifinal matches, featuring a pick on Lorenzo Musetti vs. Carlos Alcaraz.

French Open predictions

Best bet: Sinner/Djokovic over 36.5 games (-108)

Sinner is on an incredible run. He’s won all 15 sets at the French Open without needing a single tiebreaker.

It’s quite the feat, but I have to take a deeper dive.

  • Sinner’s highest-ranked opponent to this point was Andrey Rublev (No. 15).
  • Djokovic (No. 6) is on a different level. He won two of the past four French Opens and still looks like he’s in his prime.
  • The Serbian is 9-2 on clay this year and has only dropped one set himself at Roland Garros.
  • That came against Alexander Zverev (No. 3), who was last year’s runner-up at this event.

After dropping the first set in that quarterfinal match, Djokovic went on to dominate Zverev. He won the next three while only dropping nine games in the process.

These two players are arguably the most calculated in the world at their craft, and I expect Friday to be a high-level chess match that extends into the later sets.

Key stat: Sinner and Djokovic’s last meeting at a Grand Slam (2024 Australian Open) went over this total. The match finished with 37 games despite only needing four sets.

Go to full French Open betting markets.

Best men’s quarterfinal tennis pick

Musetti/Alcaraz under 34.5 games (-113): Musetti has developed into a fantastic clay-court player, but this is a matchup where he continues to fall short.

His 19-3 record on the surface in 2025 rivals the best in the game, but he meets his match on Friday.

  • Alacaraz is arguably the best player on clay in the world, demonstrated by his 161-36 career record (20-1 in 2025).
  • The Spaniard has owned his Italian counterpart on clay, beating him twice on the surface already this year.

Alcaraz won four of the five sets in those meetings.

Their three-set match at this year’s Monte-Carlo Masters went well below this total (3-6, 6-1, 6-0) thanks to Alcaraz’s dominance and ability to break Musetti.

There is the possibility for five sets at the French Open, as it is a Grand Slam major, but it shouldn’t matter.

Alcaraz has won five matches in a row vs. Musetti and eight of nine sets in those contests.

Backing this pick over Alcaraz -2.5 sets (+112) gives extra insurance to cover a shorter four-set contest.

French Open predictions made at 10:25 a.m. on 06/05/2025.

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Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.