NFL Week 15 odds and betting lines: Bills visit Lions in potential Super Bowl preview

NFL Week 15 odds

One game stands above the rest in Week 15 with all of the bye weeks officially over.

The latest: All will be tuned into Sunday’s tilt between the Buffalo Bills and Detroit Lions. The week starts with an intriguing contest, too, as the San Francisco 49ers welcome the Los Angeles Rams. The Battle of Pennsylvania will be worth watching as the Philadelphia Eagles host the Pittsburgh Steelers.

Check out the latest NFL Week 15 odds below.

NFL Week 15 odds

Los Angeles Rams vs. San Francisco 49ers

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Baltimore Ravens vs. New York Giants

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New York Jets vs. Jacksonville Jaguars

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Washington Commanders vs. New Orleans Saints

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Cincinnati Bengals vs. Tennessee Titans

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Miami Dolphins vs. Houston Texans

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Kansas City Chiefs vs. Cleveland Browns

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Dallas Cowboys vs. Carolina Panthers

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New England Patriots vs. Arizona Cardinals

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Tampa Bay Buccaneers vs. Los Angeles Chargers

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Buffalo Bills vs. Detroit Lions

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Indianapolis Colts vs. Denver Broncos

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Pittsburgh Steelers vs. Philadelphia Eagles

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Green Bay Packers vs. Seattle Seahawks

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Chicago Bears vs. Minnesota Vikings

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Atlanta Falcons vs. Las Vegas Raiders

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Visit all of NorthStar Bets’ NFL markets. Click on game odds below to bet now.

Betting Insights

  • Los Angeles and San Francisco are still jockeying for the division title, but the loser of this game will be all but eliminated from the race. The 49ers have won three consecutive games against the Rams and six of the last eight.
  • There’s not a lot of history between the Buccaneers and Chargers, but this could be a fun contest. Both Justin Herbert and Baker Mayfield are playing fantastic football. Overs have been a common occurrence for the Bucs, as they boast an elite offence but a porous defence.
  • The Bills and Lions have legitimate Super Bowl aspirations, and the two meet in a game with significant playoff implications. Buffalo aims to keep pace with Kansas City for first in the AFC, while Detroit strives to stay ahead of the Eagles.
  • Pittsburgh meets its toughest test yet with a road date against Philadelphia. Playoff positioning is key for both teams in this contest. The Steelers are still vying for first in the AFC North, while the Eagles continue to breathe down the Lions’ necks.
  • There are two Monday Night Football games in Week 15. The Bears visit the Vikings in an NFC North showdown before the Falcons and Raiders meet in Las Vegas shortly after.
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Stevie’s an avid NFL, NHL, and tennis bettor who has no problem talking himself into the underdog. His previous stops include Yahoo! Sports Canada and Toronto Metropolitan University, where he received a degree in Sport Media.