The injury-riddled San Francisco 49ers visit the Buffalo Bills on Sunday Night Football.
The pregame narrative: The Bills are playing inspired football right now and I feel good about Buffalo winning by at least a touchdown. The over also has value with all the offensive firepower in this game.
Check out my 49ers vs. Bills best bets for the Week 13 Sunday Night Football matchup.
49ers vs. Bills best bets
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Best bet: Bills -6 (-110)
What a time to be a Bills fan. The team is cooking right now, led by Josh Allen, who’s making a real case for MVP.
The Bills have scored 30 or more points in five straight weeks. That includes a 30-21 win to hand the Kansas City Chiefs their first loss of the season.
Brock Purdy is questionable for the 49ers but was limited on Thursday. He reportedly threw just two passes at Wednesday’s practice before calling it a day.
Even if Purdy plays, it is quite clear his shoulder is not in good shape.
Either way, I like this line but it’s worth monitoring Purdy’s availability as it would certainly move if he was ruled out.
With or without its QB, San Francisco’s defence is more vulnerable now than in years past.
- The 49ers allow the 13th most points per game (23.6)
- Seven straight opponents have scored 20 or more against San Fran
- The defence allows a 43.7% conversion rate on third down
All three of those stats are concerning for the 49ers and I love the Bills to cover at home on Sunday Night Football.
Key stat: Buffalo is 5-0 at home this season with a +79 point differential.
Quick pick
Over 43.5 points (-134): During the Bills’ six-game win streak, every contest has gone over 40 points. Four cleared this total while the other two ended on 41 and 43.
I believe Buffalo can single-handedly cover most of these points, but I also think the 49ers can contribute a couple of scores.
If Purdy plays, this number gets more enticing. But if he doesn’t, there’s plenty of talent on the 49ers offence to pick up the slack.
Christian McCaffrey, George Kittle and Deebo Samuel are all healthy. I can’t see McCaffrey having another yards per carry of 2.8 like he did last week.
After all, the star back has a 4.7 career YPC and has shown he can get it done regardless of who’s at QB.
Even with the 49ers having a terrible offensive game last week, they lost 38-10 and the contest still went over this total.
Picks made at 5:28 p.m. ET 11/29/2024.
Spencer is a true sports junkie. A graduate of the Sports Journalism program at Centennial College, he first joined NorthStar Gaming as an intern in 2023. He is now a contributing writer. He loves finding the edge to bet on in all sports but has a deep passion for the NBA and UFC. Previous stops include Sportsnet.