Another week, another NFL slate loaded with betting opportunities.
There are 11 games coming at you this Sunday, including a San Francisco 49ers and Green Bay Packers rematch from last year’s NFC Divisional Round and a Sunday Night Football showdown between two red-hot teams.
Check out our Week 12 NFL betting guide, featuring staff picks and predictions to help you make the best wagers.
NFL betting guide: Week 12
Don’t be surprised if you see some blowouts to start the day.
Five of the seven games in the 1 p.m. ET window have spreads of 7.5 points or greater. That includes a matchup between the Kansas City Chiefs and Carolina Panthers.
Patrick Mahomes and Co. look to rebound from their first loss since Christmas Day 2023 while Bryce Young hopes for a third straight win.
The slate really gets cooking in the afternoon when the 49ers take on the Packers at Lambeau Field. But San Francisco will be doing so without two key pieces: QB Brock Purdy and star DE Nick Bosa.
At the same time, the Seattle Seahawks and Arizona Cardinals meet in a crucial NFC West matchup with pick’em odds.
A SNF matchup between the Philadelphia Eagles and Los Angeles Rams closes things out.
Philly is a perfect 6-0 since its bye and is steamrolling teams. L.A., meanwhile, has won four of its last five and is putting up massive numbers with Puka Nacua and Cooper Kupp in the mix.
Here are some quick betting notes for Sunday:
- Highest total: Lions vs. Colts (50)
- Biggest spreads: Chiefs (11) vs. Panthers; Cowboys vs. Commanders (-10.0)
- Seven teams have odds of +200 or longer to win (Cowboys, Colts, Panthers, Patriots, Giants, Titans, Raiders)
Lines and odds are listed as of 4:00 p.m. ET on Nov. 22.
For the latest, visit our NFL Week 12 markets. And be sure to check out the latest injury news from around the league.
Now, see how our staff is wagering on this slate.
Week 12 betting predictions
If you need a one-stop shop for spread bets, we have you covered.
Our NFL Week 12 ATS picks, via Avery Perri, Jordan Horrobin, Spencer Closs and Chris Toman, provide a recommendation against the spread for every game.
We have plenty of other picks, too.
Upset picks: It’s Tommy DeVito time in New York and Perri expects the undrafted signal caller to pick up where he left off… winning games and making hand gestures.
Parlay picks: Betting against the Cowboys, Titans and Raiders has been awfully profitable this year, and now you can fade all three in one place with Horrobin’s +256 parlay.
TD picks: Perri is locking in on two players from Sunday’s Buccaneers vs. Giants game to score alongside a rookie quarterback with a strong rushing pedigree.
Prop picks: Nico Collins, De’Von Achane and Jayden Daniels are the subjects of this week’s NFL prop picks.
49ers vs. Packers same-game parlay: San Francisco has won consecutive games against Green Bay by the skin of its teeth but Horrobin expects the Packers to at least keep this one close at home. Josh Jacobs and Jauan Jennings also factor into this +325 wager.
Sunday and Monday Night Football predictions
Eagles vs. Rams prop picks: DeVonta Smith is out for Philadelphia. Steven Psihogios expects a pair of Eagles receivers to step up in his absence and have monster performances.
Eagles vs. Rams same-game parlay: Looking for a ticket with some juicy odds? Psihogios has a +550 ticket that includes A.J. Brown and Dallas Goedert.
Ravens vs. Chargers best bets: Justin Herbert is slicing up opposing defences. That’s bad news for a Baltimore squad that can’t stop anything. Psihogios expects the L.A. QB to dominate in a winning effort.
Ravens vs. Chargers same-game parlay:
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