There are a few key storylines to watch during Sunday’s 12-game NFL slate.
Christian McCaffrey returns for the San Francisco 49ers to take on Baker Mayfield and the Tampa Bay Buccaneers. Before that, two of the league’s biggest surprises — the Pittsburgh Steelers and Washington Commanders — battle in the nation’s capital.
Check out our Week 10 NFL betting guide, featuring staff picks and predictions to help you make the best wagers.
NFL betting guide: Week 10
Be prepared for a few possible blowouts this weekend.
Seven of Sunday’s 12 games feature spreads of six points or greater. That starts in Germany, where the New York Giants are favoured to beat the Carolina Panthers.
If that game doesn’t pique your interest, we don’t blame you.
After that, the Kansas City Chiefs look to remain perfect and are the biggest favourites on the board, while the Dallas Cowboys hope for a miracle win over the Philadelphia Eagles with Cooper Rush at the helm.
The slate saves its best game for last as the red-hot Detroit Lions travel to Houston to take on the Texans on Sunday Night Football.
Here are some quick betting notes for Sunday:
- Highest total: 49ers vs. Buccaneers (50.5)
- Biggest spreads: Broncos vs. Chiefs (-8); Titans vs. Chargers (-7.5), Eagles (7.5) vs. Cowboys
- Seven teams have odds of +200 or longer to win (Panthers, Broncos, Jaguars, Patriots, Buccaneers, Titans, Cowboys)
Lines and odds are listed as of 2:30 p.m. ET on Nov. 8.
For the latest, visit our NFL Week 10 markets. And be sure to check out the latest injury news from around the league.
Now, see how our staff is wagering on this slate.
Week 10 betting predictions
If you need a one-stop shop for spread bets, we have you covered.
Our NFL Week 10 ATS picks, via Avery Perri, Jordan Horrobin, Spencer Closs and Chris Toman, provide a recommendation against the spread for every game.
We have plenty of other picks, too.
Upset picks: Can Bryce Young keep things rolling? Horrobin thinks so. Last year’s No. 1 pick re-took the starting job in Week 9 and secured Carolina’s second win of the season. Now he gets to play the downtrodden Giants in Germany.
Parlay picks: Three moneyline picks make up Perri’s +419 parlay, including the Steelers. Mike Tomlin has a spectacular record against rookie QBs and Pittsburgh has been perfect after the bye for seven straight seasons.
TD picks: Jalen Hurts is calling his own number at an absurd rate. He’s a great value to score against the Cowboys and so is a certain 49er not named CMC.
Prop picks: Travis Kelce, Marvin Harrison Jr. and J.K. Dobbins make up Horrobin’s prop picks. He’s backing one and is fading the others.
McCaffrey prop odds and best bet: Last year, CMC led the league in TDs, rushing yards, and scrimmage yards. Check out all of his prop markets against the Buccaneers plus a best bet.
SNF and MNF predictions
Lions vs. Texans prop picks: C.J. Stroud has been an absolute dawg … at home. Luckily that’s where he’s playing on Sunday. Perri is backing Houston’s signal caller and one of Detroit’s running backs.
Dolphins vs. Rams best bets: Here come the Rams! Los Angeles’ offence is finally healthy and Closs is looking to back it in more ways than one on Monday Night Football.
Visit our football vertical for complete NFL coverage, including the latest Super Bowl odds.
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